Erwin Chargaff Essays - Genetics, Nucleobases, Nucleic Acids

Erwin Chargaff Erwin Chargaff, born 1905 in Czernowiz, Austria, was a pioneer in biochemistry contributing to the understanding of DNA. He, in 1928, earned his doctoral degree in chemistry at the University of Vienna's Spath's Institute in 1928. Erwin began his career in biochemistry at Yale University, working under Rudolph J. Anderson from 1928 to 1930. His early work included stories of the complex lipids, the fats or fatty acids that occur in microorganisms. Helping discover the unusual fatty acids and waxes in acid-fast mycobacteria led him to study the metabolism and biological role of lipids in the body. Chargaff was also a pioneer in the use of radioactive isotopes of phosphorus as a tool to study in the synthesis and breakdown of phosphorus-containing lipid molecules in living cells. He published a paper on the synthesis of a radioactive organic compound called alpha-glycerophosphoric acid. He began to study nucleic acids in 1944, while at Colombia. Until this time scientists believed that amino acids carried genetic information. DNA was also believed to contain the tetranucleotides made up of cytosine, thymine, adenine and guanine, that served as an attachment site for the amino acids that made up genes. It was already known that a cell's nucleus is comprised in part by DNA, Chargaff was able to determine how much of which bases were present by measuring the amount of light each quantity of base absorbed. He showed that adenine and thymine occur in DNA in equal proportions in all organisms and that cytosine and guanine are also found in equal quantities. Chargaff's major conclusion is that DNA carries genetic information, and the number of different combinations in which the four nucleic acids appear in DNA provides enough complexity to form the basis of heredity. Finally, he concluded that the identity of combinations differs from species to species and that DNA strands differ from species. Overall, his findings were important contributions in biochemistry, including the addition of a key piece in the puzzle of the structure of DNA. This all led to major developments in the field of medical genetics, and, ultimately helped pave the way for gene therapy and the birth of the biotechnology industry.

Sheppard v Maxwell essays

Sheppard v Maxwell essays The wife of Dr. Sam Sheppard(Marilyn Sheppard) was bludgeoned to death on July 4, 1954. She was found in the upstairs bedroom of her home in Bay Village, Ohio. The town mayor called the local police, Dr. Sheppards brother(also a doctor) and the next door neighbors. Local police advised the local coroner and the Cleveland Police Department. When the coroner arrived, he pronounced Marilyn Sheppard dead, examined Dr. Sheppard and took him to a clinic(run by Dr. Sheppard). Both Dr. Sheppard and the neighbors were investigated by Cleveland police. Dr. Sheppard was later interrogated while sedated in a hospital bed. He was also questioned with out the presence of his attorney. On July 7, the day of Marilyn Sheppards funeral, the Sheppard family refused immediate questioning and full cooperation. On July 8, Dr. Sheppard was served a subpoena and cooperated fully from that point on. The next day, he reenacted the evening of his wifes murder for the coroner(Dr. Gerber), the police, and news reporters(from which there was a detailed news casting). July 20, front page editorial that Sheppard was getting away with murder due to friendships, and hired lawyers. On July 26, Detective McArthur declared that the crime scene was tampered with. It was revealed to police that Dr. Sheppard had an extramarital affairs with a woman named Susan Hayes. He was finally arrested on July 30 at his fathers home, arraigned immediately and held over for a grand jury trial. August 17, Dr. Sheppard was indicted on the count of murder. He released a statement declaring his innocence the day after his indictment. His trial started two weeks before November General Elections. Chief Prosecutor was a candidate for judge, Judge Blythin(trial judge) was running for reelection. Jury selection started October 18, this was a highly publicized trial which lasted only nine weeks. Dr. Samuel Sheppard was found guilty of murder. ...

W1 BA541 Asign Behavior vs Communication Essay Example | Topics and Well Written Essays - 1000 words

W1 BA541 Asign Behavior vs Communication - Essay Example ranch of knowledge that deals with the creation and use of technical means and their interrelation with life, society, and the environment† (Dictionary.com Unabridged, n.d.). As such, it could be deduced that interactive technologies, in the context of organizations and customers, mean the field of discipline that uses continuous two-way exchange or sharing of information between customers and the organization, on matters pertaining to the products or services offered and purchased by the clientele. As indicated, the emergence of new interactive technologies; meaning, the use of digital media (â€Å"combinations of electronic text, graphics, moving images, and sound, into a structured digital computerised environment that allows people to interact with the data for appropriate purposes† (England & Finney, 2011, p. 2), is not sufficient to presume that a solid bond is established between customers and the organization. The mere existence of these diverse kinds of interactive technologies does not firmly confirm that customers are able to grasp what the organization offers – if these are not effectively communicated to them. create new processes that are oriented around the coordination of all these newly possible customer interactions. And they must ensure that the interactions themselves not only run efficiently but are effective at building more solid, profitable relationships with customers† (p. 193). The key element that would allegedly enhance the knowledge on their products and services being offered; as well as on the organization’s ability to address the customers’ needs, is through effective communication. It was thereby emphasized that â€Å"the enterprise has to integrate all of its customer-directed communication channels so that it can accurately identify each customer no matter how an individual customer or a customer company contacts the enterprise† (Peppers & Rogers, 2010, p. 193). Concurrently, communication alone is still not enough.

Issue of Gender and Racial Discrimination in the US Essay

Issue of Gender and Racial Discrimination in the US - Essay Example Overly, despite these drastic demographic changes, the  connotation  of citizenship and the ability to treat or cure various germ and contagion related chronic infections were consistently blamed on the foreigners. This article’s key structure, therefore, revolves around three periods of immigration historical events, which include the 19th Century at around 1924, an era of retrenchment period of 1924-1965, and 1965 that was marked by an outrageous immigrant’s domination into American society (Markel & Stern, 2002). An outstanding quote in this article towards the understanding of feminist studies is, â€Å"If the relevant authorities and anti-immigration advocates found that one immigration classification is the most objectionable, they will soon mitigate every drawback in the United States associated with immigration† (Markel & Stern, 2002). This article presents racial discrimination, diseases and significantly the meaning of public change in feminist studies. This article beyond any reasonable doubt draws on archival registers in California’s Imperial Valley in the years 1940. These events resulted in the arrest and deportation of various groups of Mexican workers, some of whom presented themselves passionately as human rights union activists. These workers had entered the country legally and had inhabited the United States for many years. According to the immigrants’ officials, they rendered these activists â€Å"likely to become a public change† LPC, which was unlawful in America as a deportable offense (Natalia, 2010). According to me, I am in agreement with this author’s main points of argument. Firstly, immigration is one of the factors that have affected the American economic growth for quite a long period. In the 1940s, United States border patrol agents experienced intriguing migrato ry records into America. This experience, in turn, spearheaded the deportation proceedings for Mike Gutierrez, who acted as the president of a Congress of Industrial Organisations (CIO) local.

BFS 3430-09D, PRINCIPLES OF FIRE BEHAVIOR (BFS3430-09D) Essay - 2

BFS 3430-09D, PRINCIPLES OF FIRE BEHAVIOR (BFS3430-09D) - Essay Example Be sure to divert the spilled fuel away from the cockpit or cabin; and take extra precaution against any possibility of fuel burst out, set up a safety border within the region of the incident site (Union County Standard Operating Guidelines n.d.). 3. For fire related incidents, full protective gear must be worn including SCBAs and move towards the fire from the windward side. If no hazardous materials or explosives are present, go about the procedure as a flammable liquid fire (Union County Standard Operating Guidelines n.d.). Foam must be used in fire fighting when Jet A fuel is involved. If foam is not available make use of a semi-fog stream to push the fire away from the cockpit or cabin. Make sure that the fuel spill and fire does not flow back behind you while protecting the crew and advancing towards the fire as this may trap you (Union County Standard Operating Guidelines n.d.). 4. If the fire involves hazardous and explosive materials, follow the Hazardous Materials resources guide for the product involved, and set up a safety perimeter around the incident site (Union County Standard Operating Guidelines

Tata Steel Marketing Strategy

Tata Steel Marketing Strategy In this report, Tata Steel Group (Tata Steel) has been chosen as an organisation to analyze the strategic changes made over past five years including strategic positioning, strategic capability, SWOT and drivers behind these changes. Tata Steel currently is a major player in global steel industry. In year 2005 (Figure 1), Tata Steel operation was mainly focused in Indian subcontinent and revenue generated was close to US$ 5.0 billion only. However their initiative to expand their operations globally proved very successful over last five years. From being a mere local steel producer, they transformed themselves into a major global player in steel producers (Figure 2). They have been aggressively involved in capacity expansion by acquisitions and organic growth. Business Standard once commented that Tata Steel moved into its next target to become the worlds second largest steel company by 2012 with the help of its most expensive bet worth US$ 12.9 billion on Corus Group. Last two years has been very difficult period to global steel industry because of worldwide recession. The global crude steel production for year 2009 was 1220.0 mpta (million tonne per annum) as reported by World Steel Association lower by 8% against that of 2008. The decline in demand was due to deterioration in economy experienced by key steel end users. Table 1, shows the growth/decline in terms of crude steel production for the top ten steel producing nations. However, by acquisition of Corus and other assets, Tata Steel now ranks among worlds top ten (Table 2) largest steel producers with current steel production capacity of 32.0 mpta. After five years of its expansion programme, Tata Steel is now worlds second most geographically diversified steel producers. Mission Statement In its mission statement Tata Steel expresses that while honesty and integrity are the essential ingredient of a strong and stable enterprise, profitability provides the main spark for economic activity. Founded way back in 1907, Tata Steel stress on their core ideology in its vision statement by making emphasis on their people, supplier of choice, innovative approach and their conduct. Tata Steels vision statement is now became a tangible asset, which provide right direction to their managers and employees. Tata Steel has highly skilled employee asset of 81,000 spread over five continents. Tata Steel stress on creating differential value for their customer with help of continuous improvement in their business process and product technology. Value Chain Analysis The value chain is an economic tool used to determine the strategic resources available to a company. Basic principle of the Value Chain Analysis is that the basis for a competitive advantage of a firm lies primarily in the application of the bundle of valuable resources at the firms disposal. To transform a short-run competitive advantage into a sustained competitive advantage requires that these resources are heterogeneous in nature and not perfectly mobile (Barney, 1991, p105-106; Peteraf, 1993, p180). Effectively, this translates into valuable resources that are neither perfectly imitable nor substitutable without great effort (Barney, 1991, p117). Tata Steel has few major strategic capabilities which are valuable, unique and non-substitutable. Tata Steels Strategic Capabilities Tata Steels strategic capabilities are presented in Table 3, below. Table 3 ÂÂ   Resources Competences Threshold Capabilities Threshold Resources Threshold Competences Steel production plants at various geographical locations. Production and Sales management. Offices and buildings at various geographical locations. All other general management skills. Sufficient supply of raw materials for steel making. Sophisticated IT skills. Sufficient cash flow. Safety management. Pool of skilled personnel. Excellent customer service. IT System in place. Efficient management structure. Logistic, freight and shipment facilities. Effective employee welfare system. Capabilities for Competitive Advantage Unique Resources Unique Competences Varieties of products which caters to industries like Infrastructures, Automobiles, Aviation, Energy etc. Very competent sales team with high negotiation skills which create market for their products. Tata and Corus brands. Excellent use of IT systems for very effective use in sales process. Highly capable management team. Continuous developing and upgrading new products to serve different industry levels. Online portal Metal junction for buyers. Highly skilled managers and directors who improve and support the company success. A century experience in steel making. Integrated supplier and buyer management. Strong financial backing from group. Lowest cost steel producer in world. Very strong presence in India which is a big market for their products. Enterprise Risk Management (ERM) to eliminate risk associated with various processes. First mover advantage through innovative products processes. Continuous Improvement Process (CIP). Excellent RD for cutting edge technology and products. Operational efficiency and excellent quality control. Many proprietary products such as Tata Tiscon etc. Long-term relationship with buyers and suppliers. Porters Five Forces Analysis Tata Steel has registered double digit growth in past few years except their European business. By applying Porters Five Forces analysis principal, we can evaluate the Tata Steels market competitiveness and its current and future strategy towards intense competition faced at various fronts. Threat of New Entrants: Low Threat to new entrants in any industry sector is a major challenge. However in steel industry entry barrier is high hence threat of new entrants are relatively low based on factors such as huge capital investment, economies of scale, government policies and product differentiations. Steel industry requires huge capital investment to set up an integrated steel production facility plant which is currently close to US$ one billion/mtpa as per Steel Manufacturers Associations recent estimate. This deters any new entrants entering in this field. By increasing their production capacity to 50mtpa and wide variety of products they can lower their cost, hence more profit, sustainability and these conditions are unfavourable to any new entrants. Raw material is a major issue with corruption related to mining allocation and land acquisition, it makes difficult to new entrants to come in this field. Various regulatory clearance and environmental issues also pose big barriers to new entrants. Entry barriers in terms of product differentiation are very low in steel industry. Competitive Rivalry: High The steel industry is truly global in terms of competition with large steel producing countries like China significantly influencing global prices through their aggressive exports. In steel industry, branding is not very common hence little differentiation exists between their competing products. Tata Steel faces stiff competition with their competitors such as Arcelor Mittal, POSCO etc. Bargaining Power of Suppliers: High Tata Steel enjoys greater autonomy in raw materials supply as they own mines for raw material supply. Tata Steels fully integrated supply chain system keeps abundant supply of raw material for their plants. However, other steel producers, who dont have their own mines, have to rely on raw material suppliers. On global level raw material market is dominated by the three mining giants BHP Billiton, CVRD and Rio Tinto. They make mineral market as oligopolistic and supply two-thirds of the processed iron ore to steel producers hence command very high bargaining power. Other steel producers, who dont have their own mining operations, must buy raw material at market prevailing price and pass that hike to consumers which makes them less competitive. Threat of Substitute Products: Low New materials may pose threat to viability of steel. Aluminium, plastics and other composite materials are being considered as substitute in sectors like auto, aviation etc. Concrete is another substitute material that may pose threat to use of steel in infrastructure and energy sectors. Some of the substitute materials such as aluminium itself are very costly, hence doesnt pose very big threat against steel producers. However the growth led by infrastructure sector, automobile sector, aviation sector and consumable goods will keep demand up for steel hence more growth for Tata Steel. Bargaining Power of Buyers: Average Bargaining power of buyers is very limited due to their fragmentation. Big players of the major steel consumers in sectors such as auto, aviation, energy etc may squeeze greater amount of bargain. On the other hand these bulk consumers may offer long term procurement offer to the company hence more revenue generated. However, small and retail consumers are scattered, though they consume significant amount of steel production, dont have the same bargaining powers as in case of big players. Tata Steel Group SWOT Analysis SWOT analysis of any firm provides knowledge about the challenges and opportunities faced by Tata Steel group in future. They are detailed below. (S)trengths Tata Steel has acquired vast mineral reserves which is a key to their operations. These reserves can cater their raw material demand for next three decades. Tata Steels mineral reserves are located at various strategic geographical locations such as India, Australia, Canada, Mozambique, Oman, Ivory Coast etc. Tata Steel has very capable, credible and reliable top management. Their successful global expansion plan in last five years proved this. Tata Steel has successfully acquired and integrated Corus Europe, NatSteel Indonesia and Millennium Steel Thailand. Tata Steel uses custom made state of art integrated information management system for their routine operation. Their advanced RD capability has improved further by acquiring Corus which is world renowned for its product innovation. Tata Steel uses Tata Groups strong distribution and retail network. Its Groups demand for steel is very high due to their presence in most of the sectors. Currently Tata Steel produces 32 mpta of steel and by completion of DPCL project its total capacity will reach to 50mpta which will make it second biggest steel producer in world. Tata Steel has structured risk management process in place in their operation known as Enterprise Risk Management (ERM). ERMs key function is to identify risk at every level and mitigate the same. Tata Steel mitigates very well the cyclicality situation which occurs in steel industry occasionally by its broad spectrum of its product portfolio. Tata Steel expansion plan has consolidated its position worldwide and by diversifying its portfolio and market is in process to become a pioneer in steel industry. Tata Steel has very strong brand value for its products. This has strengthened further by acquiring Corus which itself is a big brand. Their successful integration with Corus was a benchmark in corporate history. (W)eaknesses Tata Steels substantial debt burden of US$9.8 billion is a major weakness. Their debt equity ratio is currently 1.77, which reflects company finances are met by debt due to Corus acquisition. Its European business (Corus) has a high exposure to spot price and a high operational gearing thus creating very high risk of price volatility. Tata Steel relies for some raw material on international suppliers, which expose their profitability in case of steep rise in their prices. Tata Steels Indian operation is very much hampered by lack of infrastructure, shortage in power supply, lesser productivity, bureaucratic hurdle in export etc. Additional levies and tax imposed by local government put them in less profit making situation. The subsidies provided by some nations (China etc) will make their product less competitive in price hence reduce their demand. (O)pportunities Currently the emerging economies are undergoing huge infrastructural developments, which require significant amount of steel in all sectors. In India the scope for expansion of its steel products are enormous in every sector, which Tata Steel can exploit very well with its increased production capacity. As per World Steel Association estimate, the consumption of steel will be doubled in next two decades. By Acquiring Corus and improving its own RD activities, Tata Steel moved towards a better product differentiation and enhanced product portfolio which provide them new opportunities over its competitors. Their geographical locations with integrated operations and marketing strategy are a key factor in capturing market share and increasing their financial performance. They can implement Coruss advanced automation technology in their own plants to improve productivity, economies of scale, cost reduction, increased output and operational efficiency to achieve better performance. Following recent recession, various assets (minerals, plants facilities etc.) are available at a very low price due to their financial difficulty. Tata Steel, with strong backing from its parent group can secure future supplies of raw materials for steel making. With increased steel production capacity of 50 mpta, they will be the second largest steel manufacturer after Arcelor Mittal and most geographically diversified company with wide variety of product mix. (T)hreats Steel Industry is major source of greenhouse gas emission, which makes them very vulnerable against many litigation and legislation in future. The raw materials used in steel production are non-renewable and their source is depleting very fast. Due to rising cost of steel products, the end users are looking for substitutes of steel; which can be a major threat to Tata Steels business. Intense competition among international steel player and cheap steel available from China are another major threat to Tata Steels performance. Tata Steels huge debt is one of major threats against them. The rising interest will increase their debt burden. Future Outlook Following two years of worst global economic downturn, the world seems to be regaining some economic stability. There is moderate growth from developed world; however emerging economies are registering very strong and sustainable growth with robust domestic market. Before recession, the steel demand was very strong with over 6% growth during last decade; this is primarily driven by robust growth in BRICS nations (Brazil, Russia, India, China and South Africa), South East Asia and Middle East. By 2025, as per forecast BRICS countries will have 46% of global population and will consume 65% of the global production and will have three quarter of the global GDP. The raw materials for steel making are going at record due to high demand, higher freight rates and monopoly of three big natural resources companies. The effects of the above factors are reflected in higher steel price and decrease in profit margin of steel companies. However Tata Steels strategy adopted over last five years for securing long term contract for raw materials supply or acquiring new raw material mines at various geographical location has helped them to keep their prices competitive and making whole operation as viable. Tata Steels integration with Corus has completed successfully and producing better result than expected. Tata Steels strategic effort of capacity expansion and effort to secure raw materials source at various geographical locations yielding positive results. Tata Steels upstream integration process ambition will lead them to achieve 100% self-sufficiency in India and around 50% self-sufficiency in Europe in next 5 years. Tata Steel is investing heavily in RD to get breakthrough technologies and develop new products and services that reduce the production cost and environmental impact over the product lifecycle. To improve its processes, priority is given to energy conservation schemes; in technology break-through such as Ultra Low Carbon Steel making and in other innovative projects where the Group has proprietary technology. Conclusions It was the best of times, it was the worst of times, this famous quote meant a lot to Tata Steel. Five year back, just after starting of their ambitious global expansion plan, they were hit by worldwide financial tsunami which tested their resilience. Their well formulated and proved business strategy has shown resilience and ability to withstand the unprecedented highs and lows of a future that often comes unheralded. They have taken proactive initiative across all geographies to minimise aftermath shock of recession. Their strategy began to pay off towards the last quarter of year 2009, when they rebounded to profit after the turmoil of recession. Undeterred by the economic turbulence, the Company continued to place emphasis on working practices in health, safety and corporate citizenship, with specific initiatives taken in all these areas. In addition, a continued focus on engineering solutions for customers is helping it maintain its position of a product pioneer. Tata Steel believes in staying alert to future opportunities while never letting go of its core values. This is the philosophy that has underpinned its growth over the years and one that remains its key driving force. The strategy adopted by Tata Steel during last five years to become a global player paid off. They increased their revenue and production by six fold by capacity expansion or acquisition. They achieved raw material self-sufficiency of 50% by year 2010 and by year 2012 they aim to increase it to 60% by more investment in mines acquisition. In last five years Tata Steel became a global player from a local steel producer with currently global presence in 50 markets and manufacturing operations in 26 countries. Appendix A: Reference List Tata Steel Group Annual Report 2009-10 G Johnson, K Scholes R Whittington (2008), Exploring Corporate Strategy, 8th Edition Text Cases, Harlow: Financial Times Prentice Hall http://www.tatasteel.com Barney, J. 1991. Firm Resources and sustained competitive advantage, Journal of Management, 17 (1): pp99-120. Barney, J.1995. Looking inside for competitive advantage, Academy of Management Executive. 9(4). Pp49-61. Peteraf, M. A. (1993). The cornerstones of competitive advantage: A resource-based view, Strategic Management Journal, 14 (3), 179-191 Porter, M.E. (2008). The five competitive forces that shape strategy, Harvard Business Review, January, 78-93. Porter, M.E. (1996). What is Strategy? Harvard Business Review, Nov-Dec, 61-78.

Preparing for and Having a Baby :: Pregnancy Childbearing Essays

Preparing for and Having a Baby There are many different areas to consider when preparing for and having a newborn. Whether the pregnancy was planned or unplanned or the couple is married or not, a newborn baby brings new responsibilities. Having a baby also forces people to make adjustments both financially and within the family. Parents also express concerns and expectations when having a newborn comma especially when it is their first; including what roles each parent and family member should play, how much confidence they have in their parenting skills, and how much financial strain would be placed on the family once the newborn has arrived. The newest issue in today’s society is the fact that many women are delaying childbirth and having more children in their later years of life. This paper will examine three of the areas associated with planning a newborn child, including single parenting, concerns and expectations parents have when planning for and having a child, and financial issues that mothers face when planning a pregnancy. (Specify if you are talking about single moms or parents/couples, if talking about all of them you might want to consider narrowing your research.) (Introduce this quote, where did you find it, how did you find the site, remember that this is a narrative, you are walking me through the steps of your research. ) â€Å"Today, about one in every three U.S. births occurs outside of marriage. The proportion of births to unmarried women has risen monotonically over time, and attitudes toward non - marital fertility have become progressively more tolerant† (Musick, 2002, p. 915). Sometimes these births are planned and at other times they are not. â€Å"Dramatic increases in cohabitation and associated delays in marriage have changed the composition and character of non-marital births. Unmarried mothers now tend to be older, to have other children, and to be living with a partner at the time of their child’s birth† (Musick, 2002, p. 915). What significance does this have to your research? What does it prove? Why did you include it? The article that I researched regarding this area explores the reasons why women may be taking the steps to start a family without marriage, whether these pregnancies are planned or unplanned. The study was conducted using a couple of different methods including the National Survey of Family Growth and a Discrete-Time Hazard Model. â€Å"The National Survey of Family Growth is a periodic, nationally representative fertility survey conducted by the National Center for Health Statistics.

Human Potential – Of Mice And Men

In the novel Of Mice And Men, John Steinbeck Illustrates human potential and its effects on Lennie Crooks and George. Steinbeck suggests humans have the natural potential to seek happiness although the potential can be fatal or harmful. Although Lennie does not have the potential to be smart, Lennie has the potential to be a hard worker. However, Lennie s strength did not work with him and the result was fatal. Lennie is an extremely large man who had the strength of a bull. With the use of his strength, he was great worker but did not understand how strong he was. George explains Lennie s strength by: â€Å"that big bastard can put up more grain alone than most pairs can†( Steinbeck 34). Through his size and his enormous amount of strength Lennie could out work the other men of the ranch by himself. Through the use of Lennie s strength he became a great worker who knew nothing more than to work. Lennie uses his potential to work hard, but does not understand how strong he is. Without George, Lennie does not understand what to do. Lennie gets frightened and uses his strength to hold on to objects. Lennie is just like a child. He will do what ever George tells him to: â€Å"Curely was flopping like a fish on a line, and his closed fist was lost in Lennie s hand. George slapped [Lennie] in the face again and again and still Lennie held on(63). Through Lennie s actions we can see that Lennie is very similar to a child. Lennie s first instinct when he is scared is to hold on. Just as a little kid holds on to its mom or dad when they become frightened, Lennie holds on to objects. Because of Lennie s low intelligence to understand his strength, he becomes frightened and kills Curley s wife and as a result, she ends up being killed by is otential: â€Å"She took Lennie s hand and put it on her head And then she cried angrily. Lennie s fingers closed on her hair and hung on. He shook her and her body flopped like a fish. And then she was still†(91). Lennie did not understand his strength and became frightened, and once again just like just like a little child he held on. But he ended up breaking Curley s wife neck. As a result of his actions Lennie ended up dead. Lennie had an extremely great potential to use his strength and become a great worker. However his difficulty to understand his strength lead to his death. Unlike Lennie Crooks potential is his knowledge, and Crooks has the ability to use his knowledge to, try to escape the problems he has on the ranch. However Crooks falls back into a 1930s attitude and chooses to neglect his knowledge. Crooks also uses his knowledge to express his ideas and feelings to Lennie. â€Å"Books ain t no good. A guy needs somebody to be near him A guy goes nuts if ain t got nobody†. (72) Crooks is proving that he is a very knowledgeable man When around others he may chooses to use his knowledge to express his ideas and become a stronger influence. Crooks uses his wisdom to express his ideas and eelings and leave a very strong impact. Crooks has the likelihood to use his knowledge, but how he uses his wisdom will determine his fate. â€Å"I said s pose George don t come back no more. S pose he took a powder and just ain t coming back. What ll you do then? He won t do it Lennie cried. He ll come back tonight —†(71). Crooks is using his knowledge as a power trip on Lennie who does not understand what Crooks is saying. Crooks is doing this because he has never had a chance to use his knowledge in such way before, but is really abusing it. Crooks chooses to use his knowledge around Lennie. But when a higher authority is around Crooks chooses to ignore it for his own safety. â€Å"Listen nigger, [Curley s wife] said, (y)ou know what I can do to you if you open your trap? Crooks seemed to grow smaller, and he pressed himself against the wall. Yes ma am, and his voice was toneless†(80). When a higher authority is present Crooks chooses to ignore his knowledge because he is scared to speak out for fear of losing his job. Despite Crooks, knowledge he chooses to ignore it around higher authority, this ending up in a 1930 s attitude with his knowledge going to waste. Unlike Lennie or Crooks George has the potential to be his own boss. If George does not work hard enough his potential to be his own boss will be lost and his dream will be crushed. George has always wanted to be his own boss. When he sees that the potential is there, George tries to act on it. George says: â€Å"We d just go there, we wouldn t ask nobody if we could â€Å"(61). George would love to be his own boss and do his own thing, mainly because George would not have to take orders from any one. To accomplish being his own boss, George tries to save his money so that he can buy the ranch: â€Å"If me an Lennie work one onth an don t spen nothing, well have a hundred bucks† (60). To fulfill his potential to be his own boss, George says he will save his money and not spend any. If George can accomplish this he will be his own boss. When Lennie breaks Curley s wife s neck, George realizes that the potential to be his own boss is lost. Candy says: † You an me can get that little place, can t we George? Candy dropped his head and looked down at the hay. He knew†(94). Now that Lennie has broken Curley s wife s neck, George realizes that his possibility of being his own boss is gone. Without Lennie, George feels here is no hope. As a result the potential to be his own boss is lost. George has a great potential to be his own boss, but with the death of Lennie, George loses hope. George has chosen his fate to be a worker and not to be his own boss. In his novel, Of Mice And Men, John Steinbeck illustrates to us that all humans have the potential to do well, but how they use their potential will determine their fate. Lennie, Crooks and George all have one thing on their mind: to accomplish their potential and make it reality. If they do not use their potential It can a source of pain and an unfulfilled dream.

The Evolution of DNA

The Evolution of DNA Free Online Research Papers Man has sought answers to the meaning of life trying to understand the fundamentals of our existence. Over the past couple of decades we have been able to uncover a substantial amount of knowledge pertaining to the instructions that allow life to continue. DNA or deoxyribonucleic acid has been identified in all forms of life. We have discovered that the human genome, are the codes for manufacturing proteins, which carry out the necessary tasks to ensure the stability of life. DNA is made up of 3 components; a phosphate group, nitrogenous base, and a five-carbon sugar. Together these components form nucleotides, which in turn are bound together forming segments called genes. A gene is a sequence of base pairs coding for a specific trait or characteristic. Essentially DNA is the blue print for life. Having identified these instructions, scientists are now intrigued by the possibilities of which this new area of research is generating. Applications of this knowledge range from the simplest forms of cloning, treating hereditary illness as well as biological warfare. The pursuit of this research has raised many questions regarding ethical issues that will play a key role in any further developments. Currently the Federal Bureau of Investigation is developing techniques designed to link criminals to crime scenes. In October of 2000 they unveiled The National DNA Index System, which catalogues every U.S residents DNA sequence. This will allow authorities across the country to match criminals to crime scenes using remarkably little evidence. Another booming area of this field involves genetic manipulation. Within the next 10 to 20 years scientists predict that through laboratory breakthroughs we will have sufficient knowledge to select desi red characteristics to be displayed in our offspring. The applications and issues previously mentioned as well other hot topics of discussion will be covered in greater detail throughout this report.   DNA fingerprinting was first developed as an identification technique in 1985. Originally used to detect the presence of genetic diseases, DNA fingerprinting soon came to be used in criminal investigations and forensic science. This method of identification compares fragments of the suspects DNA and any DNA found at a particular crime scene. This procedure has proved to be the most reliable means of identification because no two persons in the world, excluding identical twins, have a matching sequence. A DNA fingerprint is constructed by extracting a DNA sample from body tissue or fluid such as hair, blood, or saliva. A process called electrophoresis creates a detailed mold of the DNA sample. Electrophoresis is the phenomenon of the movement of electrically charged particles through a gas or liquid as a result of an electric field formed between electrodes immersed in the medium. In an emulsion of rubber latex in an aqueous medium, for example, the rubber droplets tend to acquire an electrical charge opposite to their own. If this electrode has a particular shape, the rubber particles deposited on it will coalesce to form an article of this shape. The DNA fragments have a slight negative charge, so they move towards the trays positive end. (As with magnets, opposite poles attract.) But the medium acts like a strainer: Smaller DNA fragments travel through easily and thus travel farther towards opposite electrode. Radioactively labeled probes (pieces of DNA) are applied to the system. The probes attach themselves to the DNA fragments. X-ray film is applied. The radiations from the probes, which are now present at only a few locations, expose corresponding areas on the X-ray film. Scientists in coordination with the National Institute of Justice are now developing credit card sized chips that will have the ability to analyze DNA right at the crime scene. Essentially the cops go to the crime scene pick up the evidence, drop it into a cartridge and stick it into their portable reader. This tool in a matter of minutes performs the whole process of electrophoresis mentioned previously. This process is so incredibly efficient that police will not have time for a coffee, before the DNA profile is completed. This device is still being developed and is expected to be completed and ready for used within the next five years. In most cases, courts have readily accepted the reliability of DNA testing as an accurate method for acquiring evidence. However DNA fingerprinting is controversial in a number of areas: the accuracy of the results, the costs of testing, and the possible misuse of the technique. The possibility of providing our children with genetic enhancements is becoming ever closer. Scientists have hypothesized many possibilities. They include ideas such as: appearance, slowing down aging, resistance to viruses and diseases as well as intelligence. For example, the risk of heart disease depends on the levels of HDL, the good cholesterol, being present in higher levels is better. In the human body, a gene called ap0-A1 makes a major piece of HDL. In mice, its possible to acquire basically any HDL level required by introducing more copies of this gene. Theoretically this could be applied to humans. Another example of how resistance of illness can be obtained is: Those who are born with two defective copies of a gene called CCR5 can escape HIV infection despite numerous encounters. The reason is that CCR5 makes a protein that the AIDS virus locks onto when it invades white blood cells. If the there is no CCR5 protein on protruding from the cells membrane then the virus cann ot infect. Essentially, scientists predict that these alterative enhancements will be available possibly within the next 10 to 20 years. After experimenting with rodent’s intelligence through genetic engineering, scientists claim that results from the genetic enhancement suggest that an increase of mental and cognitive attributes such as intelligence and memory in mammals is feasible. For example the hippocampus, found inside the brains of mice and humans, is crucial to learning. It is here where short-term memory is transformed into long-term memory. The gene NR2B helps build a protein called NMDA, which acts as a receptor for specific chemical signals. These chemical signals train brain cells to fire in repeating patterns. They are what we experience as memories. Again, through introducing the desired genes into a freshly fertilized egg, the genetic information will be made their own and passed on through future generations. The future of this field of research looks promising. In addition to the potential to cure disease and prolong life – the use in the criminal justice system will surely continue to produce results with pinpoint accuracy. Once the backlog associated with the lengthy amount of time in which it takes to process DNA evidence is addressed it will enable the courts to clear many outstanding criminal cases. Continued research will eventually assist courts in rendering verdicts that are without controversy. As with any other form of science it may never be perfected, but its use in criminal investigations and the improvements in quality of life will far exceed any current gene mapping theory currently available. References 1.   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Haney, Daniel Q. Popular Science Online. Building a better baby. popsci.com/scitech/features/building_babies/ 2.   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Lander, Dr. Eric S. Uses of DNA in identification. http://esg-www.mit.edu:8001/esgbio/rdna/landerfinger.html 3.   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Lemonick, Michael D. Time Magazine: Canadian Edition. Smart Genes?. September 13, 1999. Page 40. 4.   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Microsoft Encarta Online Encyclopedia 2001. Electrophoresis. http://encarta.msn.com 5.   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Sinha, Gunjan. Popular Science Magazine. DNA Detectives. August 1999. Page 48. 6. Bennett, Wayne W. and Hess, Karen M., Criminal Investigation (8th Ed), 2007. Pages 133-138. Research Papers on The Evolution of DNAGenetic EngineeringRiordan Manufacturing Production PlanThe Relationship Between Delinquency and Drug UseBionic Assembly System: A New Concept of SelfStandardized TestingRelationship between Media Coverage and Social andOpen Architechture a white paperResearch Process Part OneCapital PunishmentMarketing of Lifeboy Soap A Unilever Product

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buy custom Short History of America essay Home protection was advocated for in the US which came as a result of the request of forbidding liquor which led to the considerable irresponsible behaviors in marriage. A more elaborate method of politics and economy-related issues was put in a place where a democratic right to vote was implemented. A president by the name Frances Willard was made by women to abort the misconception that they were feeble, highly parasitic and could not get on their own. The turning point of the ideology of feminism was seen at the time when much of race-related concepts and ethnic niche were governed. The ancient feminism of equal rights had never been practiced. Women were given greater consideration in the field of employment, education capacities and even politics. Some other leaders in suffrages argued that the educational concept and the voting ideologies were not in contradictions to the movements interests provided that gender equality was upheld. One National American Women Association was created in 1890 to pull bodies of suffrage that had been formed after the civil war (Drehle 624). Establishing the new imperialism took place in the late 1890s and was taken to a broad projection at its definition. This ge is dated back in the final quarter of the 19th century as dominant European powers secured substantial parts of the world to themselves. American imperialism took considerable center stage in the North American continental parts. The Monroe Doctrine made people believe that America had taken hold of the northern hemisphere. America could not get to a compromise and let itself to be outdone in the fight for imperialism. Finally, America got to be the world power in the Spanish eyes with some accidental bombing afterwards. 270 deaths were experienced which sought for diplomacy but it was never there (Zinn 626). The two texts, "The White Man's Burden," and "New York Fire Kills 148 gives the political, cultural and economic values of Americans are clearly drawn out. The history matters of the US gives an experience of the Americans all over that time. The cultural values of the Americans with Indian origin had their faith in the norm that any kind of body pain had a good recommendation from God for healing. The availability of medicine men was also upheld with a critical responsibility of giving medication and food. The Indian culture in the American ground gave for the celebration of visitors celebration overnight events (Kipling 1). Land had a great consideration as a background of the economic sector with its main product in food being tuna .The energy source at this time was mainly firewood from the timber around them that is why they had to collect it all through their journey. In this very economy the practice of medicine men also played a major role in the provision of income. That is why their influence was felt at all levels. Many of the economic activities of this time 1911 faced a lot of challenges. One most known challenge is the March, 26, 1911 which resulted to too many deaths. The society had good treatment of the fire out break at the time since the safety measure had bit improved. The hospital facilitation also shows that level of social care was up to task. Police forces at the fire site gave relevance of the political image with the government of that time. In political aspect .the police were of varied responsibilities since they were to keep calm at the same time be a rescue tool. People of the state of New York give note of fairness in judicial system since a transcript on the criminal trial against the factory was made. Investigative commission were also done to give measures of curbing such challenges as political vision (Murray 2) Buy custom Short History of America essay

Literary Perspectives on New York City History Essay

Literary Perspectives on New York City History - Essay Example This essay takes a look at the literary works of a Frances Trollope, Charles Dickens, George G. Foster and William Dean Howells with a view to presenting an overview of the wide literary perspectives on New York's history. 19th century New York was arguably a city to behold. It might not have been as glamorous as London, but it could compare favorably well with the great cities of the time, and like London compared to Liverpool, or Paris to Rouen, Trollope believes that the New York of the 19th century was the finest city in all the colonies making up America. The beauty of New York City was reported in several historical documents. The elite section of the city was well organized and richly furnished. The opulence that radiated from this section of the city was easily comparable to what was obtainable in both France and England. Though gardens and flowers in front and around houses were not a common culture as was the case then in London and Paris, the elegance of the houses and their decoration was not less enticing. In this regard, Trollope1 writes that: "Every part of their houses is well carpeted, and the exterior finishing, such as steps, railings, and door-frames, are very superior. Almost every house has handsome green blinds on the outside; balconies are not very general, nor do the houses display, externally, so many flowers as those of Paris and London; but I saw many rooms decorated within, exactly like those of an European petite maitresse" Talking about the elegance of the 19th century New York City, one meeting point for most historians was the uniqueness of the area known then as Broadway. Broadway was, reportedly, the major road that cut across the whole New York City and it brought most of the city's business and elites together. Describing Broadway as the 'main artery' of New York City, Dickens2 report that the street was about four miles long, stretching from the Battery Gardens to terminate on the opposite end in a country road. Broadway was a very busy business area and was known for its well polished pavement stone and red brick houses, neat and well organized shops well dressed pedestrians. While Dickens argues that there possibly was no other street as 'sunny as Broadway' referring to the width and space of the street; Trollope writes that for its beauty, organization and businesses, Broadway was comparable to, not only Bond Street, but also Regent Street. 1. Mrs. Trollope Visits New York City In 1832, the English novelist Frances Trollope (1780-1863) published a memoir of her recent travels in the United States. Entitled Domestic Manners of the Americans, it contained the following observations of New York as it was only a few years after the opening of the Erie Canal 2. "A Dickensian View of New York" by Charles Dickens from Charles Dickens, American Notes (1842) Beside the uniqueness of Broadway in the early New York City, one interesting fact that appears to be common to all the historians is that like their counterparts in France and England, the female New Yorker of the 19th century was astoundingly fashionable. This fact was perfectly conveyed in Dickens statement thus: "Heaven save the ladies, how they dress! We have seen more colors in these ten minutes than we should have seen

Cultural Analysis Essay Example | Topics and Well Written Essays - 2500 words

Cultural Analysis - Essay Example since the horrific images of September 11, 2001, one of the greatest obstacles proponents of a global community overcome is the image of the Muslim people as blood-thirsty, murdering terrorists. There are in fact millions of Muslims around the globe, in virtually every country of the world, who are in fact not terrorists and have little desire to do more than – like most people – provide for their families and live out their lives in a peace. In Arabic, the word â€Å"Muslim† means one who surrenders, and for Muslims the surrender to God, or Allah (Merriam Webster on-line dictionary). Mary Pat Fisher (1999) describes how the Arab people received the Word of God through the Prophet Muhammad (p. 346). Just as those whose faith rests in Judaism and Christianity, Islam can also be traced to the patriarch Abraham (p. 344). Also, just as the expression of Judaism is held within the Old Testament of the Bible, as is the expression of Christianity held in the New Testament of the Bible, the expression of Islam rests within the Qura’an (p. 344). The revelations of the Qur’an unto the Prophet Muhmmad by an â€Å"angel in human-like form, Gabriel†¦,† began about 600 C.E., which began with the words â€Å"Proclaim! (or Recite!) In the name of they lord and Cherisher, who created – created man, out of a (mere) clot of congealed blood: Proclaim! And they Lord is Most Bountiful – He who t aught (The use of) of the pen, - Taught man that which he knew not (p. 347).† The revelations made unto Muhmmad by the angel Gabriel continued â€Å"intermittently,† says Mary Pat Fisher (p. 347). The central theme of the revelations was that there was but one God, and that one God was calling the people of Islam unto Him (p. 347). The word â€Å"Islam† means â€Å"complete trusting surrender to God (p. 347).† At first Muhammad shared his revelations only with those people he believed he could trust; his wife, Khadijah; his cousin Ali; a friend named Abu Bakr; and a freed slave